| ncRNA name | hsa-miR-3163 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line WERI-RB1 |
| Methods | transfection, qRT-PCR, Western blot, CCK-8 assay, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | Overexpression of miR-3163 led to a significant decrease in ABCG2 expression. Additionally, ABCG2 loss-of-function induced anti-proliferation and apoptosis-promoting functions in RCSCs, and multidrug resistance to cisplatin, carboplatin, vincristine, doxorubicin, and etoposide was greatly improved in these cells. |
| PubMed ID | 27247490 |
| Year | 2016 |
| Title | Silencing of ABCG2 by MicroRNA-3163 Inhibits Multidrug Resistance in Retinoblastoma Cancer Stem Cells. |
| Drug-related ncRNA | NO |
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